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Article

No evidence for sex-differential transcriptomes driving genome-wide sex-differential natural selection.

American journal of human genetics - 6 Feb 2025

Ming Matthew J, Cheng Changde, Kirkpatrick Mark, Harpak Arbel

Abstract excerpt

Sex differences in human transcriptomes have been argued to drive sex-differential selection (SDS). Here, we show that previous evidence supporting this hypothesis has been largely unfounded. We develop a method to test for a genome-wide relationship between sex differences in expression and selection on expression-influencing alleles (expression quantitative trait loci [eQTLs]). We apply it across 34 human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39814022
DOI: 10.1016/j.ajhg.2024.12.016
PMCID: PMC11866945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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