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Article

Langerhans Cell Histiocytosis Associated With Renal Cell Carcinoma Is a Neoplastic Process: Clinicopathologic and Molecular Study of 7 Cases.

The American journal of surgical pathology - 1 Dec 2020

Agaimy Abbas, Bonert Michael, Naqvi Asghar, Wang Chunjie, Trpkov Kiril, Dettmar Peer, Wintzer Hanns-Olof, Stoehr Robert, Hes Ondřej, Williamson Sean R, Gibson Ian W, Hartmann Arndt

Abstract excerpt

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder composed of Langerhans cells admixed with reactive mononuclear and granulocytic cells, associated with prominent eosinophils. LCH is considered a neoplasm, driven in most cases by oncogenic RAS/RAF/MEK/ERK pathway mutations. The disease predominantly affects children. Urinary system involvement has rarely been reported in a multisystem disease...

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Identifiers

PMID: 32910018
DOI: 10.1097/PAS.0000000000001562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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