Article

Targeting RAS/MAPK Signaling in Pediatric Gastrointestinal Malignancies: Current Challenges and Future Directions

2026-03-11

Abstract excerpt

Pediatric gastrointestinal (GI) cancers are rare malignancies that differ fundamentally from their adult counterparts in molecular drivers, histology, and clinical behavior. While adult GI cancers are frequently driven by recurrent oncogenic mutations, pediatric tumors often exhibit pathway-level dysregulation involving developmental signaling networks. Among these, the RAS/MAPK pathway emerges as a central conver...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f4ad1d1a-de87-517a-ba92-9c497c63d5b5
DOI: 10.20944/preprints202603.0829.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting RAS/MAPK Signaling in Pediatric Gastrointestinal Malignancies: Current Challenges and Future DirectionsDOI 10.20944/preprints202603.0829.v1Read

A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastomaSemantic proximity Read

The Emerging Role of Ras Pathway Signaling in Pediatric Cancer.Semantic proximity Read

Pediatric low-grade glioma in the era of molecular diagnostics.Semantic proximity Read

Targeting RAS in pediatric cancer: is it becoming a reality?Semantic proximity Read

Targeting Hyperactive Ras Signaling in Pediatric Cancer.Semantic proximity Read

KRAS and RAS-MAPK Pathway Deregulation in Mature B Cell Lymphoproliferative DisordersSemantic proximity Read

Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanisms.Semantic proximity Read

Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid CancersSemantic proximity Read

RAS: Striking at the Core of the Oncogenic CircuitrySemantic proximity Read

BRAF and MEK Targeted Therapies in Pediatric Central Nervous System TumorsSemantic proximity Read

Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer.Semantic proximity Read

Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma modelsSemantic proximity Read