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Article

Targetable BRAF and RAF1 Alterations in Advanced Pediatric Cancers.

The oncologist - 1 Jan 2021

Rankin Andrew, Johnson Adrienne, Roos Alison, Kannan Geoffrey, Knipstein Jeffrey, Britt Nicholas, Rosenzweig Mark, Haberberger James, Pavlick Dean, Severson Eric, Vergilio Jo-Anne, Squillace Rachel, Erlich Rachel, Sathyan Pratheesh, Cramer Stuart, Kram David, Ross Jeffrey, Miller Vince, Reddy Prasanth, Alexander Brian, Ali Siraj M, Ramkissoon Shakti

Abstract excerpt

RAF family protein kinases signal through the MAPK pathway to orchestrate cellular proliferation, survival, and transformation. Identifying BRAF alterations in pediatric cancers is critically important as therapeutic agents targeting BRAF or MEK may be incorporated into the clinical management of these patients. In this study, we performed comprehensive genomic profiling on 3,633 pediatric cancer samples and...

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Identifiers

PMID: 32918774
DOI: 10.1002/ONCO.13519
PMCID: PMC7794197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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