Article
HLA-D and PLA2R1 risk alleles associate with recurrent primary membranous nephropathy in kidney transplant recipients.
Kidney international - 1 Mar 2021
Berchtold Lena, Letouzé Eric, Alexander Mariam Priya, Canaud Guillaume, Logt Anne-Els van de, Hamilton Patrick, Mousson Christiane, Vuiblet Vincent, Moyer Ann M, Guibert Sylvain, Mrázová Petra, Levi Charlène, Dubois Valérie, Cruzado Josep Maria, Torres Armando, Gandhi Manish J, Yousfi Nadhir, Tesar Vladimir, OndrejViklický, Hourmant Maryvonne, Moulin Bruno, Rieu Philippe, Choukroun Gabriel, Legendre Christophe, Wetzels Jack, Brenchley Paul, Ballarín Castan José Aurelio, Debiec Hanna, Ronco Pierre
Abstract excerpt
Recurrence of primary membranous nephropathy after transplantation occurs in up to 44% of patients and is driven by PLA2R antibody. Here, we asked whether genetic determinants could improve risk prediction. First, we sequenced PLA2R1 and HLA-D loci in 248 patients with primary membranous nephropathy and identified two independent single nucleotide polymorphisms (SNPs) at risk for primary membranous nephropathy at...
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