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Structures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage

4 Sept 2020

Abstract excerpt

Receptor usage that determines cell tropism and drives viral classification closely correlates with the virus structure. Enterovirus B (EV-B) consists of several subgroups according to receptor usage, among which echovirus 30 (E30), a leading causative agent for human aseptic meningitis, utilizes FcRn as an uncoating receptor. However, receptors for many EVs remain unknown. Here we analyzed the atomic structures...

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PMID: 32887891
DOI: 10.1038/s41467-020-18251-9

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