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Article

Apolipoprotein E4 exhibits intermediates with domain interaction.

Biochimica et biophysica acta. Proteins and proteomics - 1 Dec 2020

Dolai Subhrajyoti, Cherakara Sreelakshmi, Garai Kanchan

Abstract excerpt

ApoE4(C112R) is the strongest risk factor for Alzheimer's disease, while apoE3(C112) is considered normal. The C112R substitution is believed to alter the interactions between the N-terminal (NTD) and the C-terminal domain (CTD) leading to major functional differences. Here we investigate how the molecular property of the residue at position 112 affects domain interaction using an array of C112X substitutions...

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Identifiers

PMID: 32882410
DOI: 10.1016/j.bbapap.2020.140535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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