Article
The human RIT2 core promoter short tandem repeat predominant allele is species-specific in length: a selective advantage for human evolution?
Molecular genetics and genomics : MGG - 1 Jun 2017
Emamalizadeh Babak, Movafagh Abofazl, Darvish Hossein, Kazeminasab Somayeh, Andarva Monavvar, Namdar-Aligoodarzi Pegah, Ohadi Mina
Abstract excerpt
Evolutionary analyses of the critical core promoter interval support a selective advantage for expanding the length of certain short tandem repeats (STRs) in humans. We recently reported genome-wide data on human core promoter STRs that are "exceptionally long" (≥6-repeats). Near the top of the list, the neuron-specific gene, RIT2, contains one of the longest GA-STRs at 11-repeats. In the present study, we...
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