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Epigenetic pathways and plasticity in brain tumors

30 Aug 2020

Abstract excerpt

Clinical studies have shown that treating many primary brain tumors is challenging due in part to the lack of safe and effective compounds that cross the blood brain barrier (BBB) (Tan et al., 2018). However, if we were to imagine that we have ideal BBB penetrant compounds that target brain tumor cells selectively, recent studies suggest that those compounds may still not be effective due to the heterogenous...

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PMID: 32877743
DOI: 10.1016/j.nbd.2020.105060

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