Article
The antinociceptive effect and adverse drug reactions of oxycodone in human experimental pain in relation to genetic variations in the OPRM1 and ABCB1 genes.
Fundamental & clinical pharmacology - 1 Aug 2010
Zwisler Stine T, Enggaard Thomas P, Noehr-Jensen Lene, Mikkelsen Soeren, Verstuyft Céline, Becquemont Laurent, Sindrup Soeren H, Brosen Kim
Abstract excerpt
The aim of this study was to search for a possible association between the variant allele of the single nucleotide polymorphisms A118G in the OPRM1 gene and C3435T and G2677T/A in the ABCB1 gene and altered antinociceptive effect and adverse drug reactions of oxycodone. Thirty-three healthy subjects exposed to experimental pain including electrical stimulation and the cold pressor test were included. A118G: We...
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