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Article

The effects of p53 gene inactivation on mutant proteome expression in a human melanoma cell model.

Biochimica et biophysica acta. General subjects - 1 Dec 2020

Faktor Jakub, Grasso Giuseppa, Zavadil Kokas Filip, Kurkowiak Małgorzata, Mayordomo Marcos Yébenes, Kote Sachin, Singh Ashita, Ruidong Li, O'Neill J Robert, Muller Petr, Goodlett David, Vojtesek Borek, Hupp Ted

Abstract excerpt

BACKGROUND: The identification of mutated proteins in human cancer cells-termed proteogenomics, requires several technologically independent research methodologies including DNA variant identification, RNA sequencing, and mass spectrometry. Any one of these methodologies are not optimized for identifying potential mutated proteins and any one output fails to cover completely a specific landscape. METHODS: An...

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PMID: 32866596
DOI: 10.1016/j.bbagen.2020.129722

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