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Article

A new rapid and simple colorimetric method to detect pyrazinamide resistance in Mycobacterium tuberculosis using nicotinamide.

The Journal of antimicrobial chemotherapy - 1 Aug 2006

Martin Anandi, Takiff Howard, Vandamme Peter, Swings Jean, Palomino Juan Carlos, Portaels Françoise

Abstract excerpt

OBJECTIVES: The purpose of this study was to develop and assess a rapid method for pyrazinamide resistance detection in Mycobacterium tuberculosis using nicotinamide in a colorimetric resazurin assay. METHODS: We have tested M. tuberculosis isolates using nicotinamide in a 96-well format with the redox indicator resazurin (REMA) and compared results using the BACTEC 460-TB system with two concentrations of...

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Identifiers

PMID: 16751203
DOI: 10.1093/jac/dkl231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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