Sex differences in brain atrophy in multiple sclerosis.

doi:10.1186/s13293-020-00326-3

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Article

Sex differences in brain atrophy in multiple sclerosis.

Biology of sex differences - 28 Aug 2020

Voskuhl Rhonda R, Patel Kevin, Paul Friedemann, Gold Stefan M, Scheel Michael, Kuchling Joseph, Cooper Graham, Asseyer Susanna, Chien Claudia, Brandt Alexander U, Meyer Cassandra Eve, MacKenzie-Graham Allan

Abstract excerpt

BACKGROUND: Women are more susceptible to multiple sclerosis (MS) than men by a ratio of approximately 3:1. However, being male is a risk factor for worse disability progression. Inflammatory genes have been linked to susceptibility, while neurodegeneration underlies disability progression. Thus, there appears to be a differential effect of sex on inflammation versus neurodegeneration. Further, gray matter (GM)...

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Identifiers

PMID: 32859258
DOI: 10.1186/s13293-020-00326-3
PMCID: PMC7456053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.