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Article

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.

Developmental biology - 15 Feb 2009

Maitra Meenakshi, Schluterman Marie K, Nichols Haley A, Richardson James A, Lo Cecilia W, Srivastava Deepak, Garg Vidu

Abstract excerpt

Congenital heart disease is the most common type of birth defect with an incidence of 1%. Previously, we described a point mutation in GATA4 that segregated with cardiac defects in a family with autosomal dominant disease. The mutation (G296S) exhibited biochemical deficits and disrupted a novel interaction between Gata4 and Tbx5. To determine if Gata4 and Tbx5 genetically interact in vivo, we generated mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA4 Transcription Factor

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Share to Heart Defects, Congenital

Share to Myocytes, Cardiac

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Source

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Identifiers

PMID: 19084512
DOI: 10.1016/j.ydbio.2008.11.004
PMCID: PMC2651674

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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