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Using the Jurkat reporter T cell line for evaluating the functionality of novel chimeric antigen receptors

22 Feb 2023

Abstract excerpt

Background: T cells that are genetically modified with chimeric antigen receptor (CAR) hold promise for immunotherapy of cancer. Currently, there are intense efforts to improve the safety and efficacy of CAR T cell therapies against liquid and solid tumors. Earlier we designed a novel CAR backbone (FiCAR) where the spacer is derived from immunoglobulin (Ig) -like domains of the signal-regulatory protein alpha...

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PMID: 39086686
DOI: 10.3389/fmmed.2023.1070384

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