Article
The primary IgM antibody repertoire: a source of potent idiotype immunogens.
European journal of immunology - 1 Jul 2001
Reitan S K, Hannestad K
Abstract excerpt
A widely held view is that, to elicit adaptive immune responses, most protein antigens must be given with adjuvants that activate the innate immune system. It has also been proposed that the immune system is tolerant to idiotypes (Id) of the syngeneic primary antibody (Ab) repertoire. We now show that among 73 purified noncomplexed secretory IgM monoclonal antibodies (mAb), 4 (5.5%) elicited high levels of IgG Ab...
Topics
- Animals
- Antibodies, Anti-Idiotypic
- Antibodies, Monoclonal
- Endotoxins
- Gene Rearrangement, B-Lymphocyte
- Immunoglobulin Fragments
- Immunoglobulin G
- Immunoglobulin Idiotypes
- Immunoglobulin M
- Mice
- Mice, Inbred BALB C
- Mutation