Article
Functional genomic analysis identifies drug targetable pathways in invasive and metastatic cutaneous squamous cell carcinoma.
Cold Spring Harbor molecular case studies - 1 Aug 2020
Anderson Ashley N, McClanahan Danielle, Jacobs James, Jeng Sophia, Vigoda Myles, Blucher Aurora S, Zheng Christina, Yoo Yeon Jung, Hale Carolyn, Ouyang Xiaoming, Clayburgh Daniel, Andersen Peter, Tyner Jeffrey W, Bar Anna, Lucero Olivia M, Leitenberger Justin J, McWeeney Shannon K, Kulesz-Martin Molly
Abstract excerpt
Although cutaneous squamous cell carcinoma (cSCC) is treatable in the majority of cases, deadly invasive and metastatic cases do occur. To date there are neither reliable predictive biomarkers of disease progression nor FDA-approved targeted therapies as standard of care. To address these issues, we screened patient-derived primary cultured cells from invasive/metastatic cSCC with 107 small-molecule inhibitors....
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