Identification of a subset of patients with acute myeloid leukemia characterized by long-term<i>in vitro</i>proliferation and altered cell cycle regulation of the leukemic cells

Abstract excerpt

OBJECTIVE: The malignant cell population of acute myeloid leukemia (AML) includes a small population of stem/progenitor cells with long-term in vitro proliferation. We wanted to compare long-term AML cell proliferation for unselected patients, investigate the influence of endothelial cells on AML cell proliferation and identify biological characteristics associated with clonogenic capacity. METHODS: Cells were...