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Article

Oncogenic NRAS Primes Primary Acute Myeloid Leukemia Cells for Differentiation.

PloS one - 1 Jan 2015

Brendel Cornelia, Teichler Sabine, Millahn Axel, Stiewe Thorsten, Krause Michael, Stabla Kathleen, Ross Petra, Huynh Minh, Illmer Thomas, Mernberger Marco, Barckhausen Christina, Neubauer Andreas

Abstract excerpt

RAS mutations are frequently found among acute myeloid leukemia patients (AML), generating a constitutively active signaling protein changing cellular proliferation, differentiation and apoptosis. We have previously shown that treatment of AML patients with high-dose cytarabine is preferentially beneficial for those harboring oncogenic RAS. On the basis of a murine AML cell culture model, we ascribed this effect...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25901794
DOI: 10.1371/journal.pone.0123181
PMCID: PMC4406710

Genes

NRAS
MEIS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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