Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program.

doi:10.1371/journal.pone.0237430

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Article

Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program.

PloS one - 1 Jan 2020

Serper Marina, Vujkovic Marijana, Kaplan David E, Carr Rotonya M, Lee Kyung Min, Shao Qing, Miller Donald R, Reaven Peter D, Phillips Lawrence S, O'Donnell Christopher J, Meigs James B, Wilson Peter W F, Vickers-Smith Rachel, Kranzler Henry R, Justice Amy C, Gaziano John M, Muralidhar Sumitra, Pyarajan Saiju, DuVall Scott L, Assimes Themistocles L, Lee Jennifer S, Tsao Philip S, Rader Daniel J, Damrauer Scott M, Lynch Julie A, Saleheen Danish, Voight Benjamin F, Chang Kyong-Mi

Abstract excerpt

BACKGROUND & AIMS: Given ongoing challenges in non-invasive non-alcoholic liver disease (NAFLD) diagnosis, we sought to validate an ALT-based NAFLD phenotype using measures readily available in electronic health records (EHRs) and population-based studies by leveraging the clinical and genetic data in the Million Veteran Program (MVP), a multi-ethnic mega-biobank of US Veterans. METHODS: MVP participants with...

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PMID: 32841307
DOI: 10.1371/journal.pone.0237430
PMCID: PMC7447043

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