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Article

Genome-Wide Association Study of NAFLD Using Electronic Health Records.

Hepatology communications - 1 Feb 2022

Fairfield Cameron J, Drake Thomas M, Pius Riinu, Bretherick Andrew D, Campbell Archie, Clark David W, Fallowfield Jonathan A, Hayward Caroline, Henderson Neil C, Joshi Peter K, Mills Nicholas L, Porteous David J, Ramachandran Prakash, Semple Robert K, Shaw Catherine A, Sudlow Cathie L M, Timmers Paul R H J, Wilson James F, Wigmore Stephen J, Harrison Ewen M, Spiliopoulou Athina

Abstract excerpt

Genome-wide association studies (GWAS) have identified several risk loci for nonalcoholic fatty liver disease (NAFLD). Previous studies have largely relied on small sample sizes and have assessed quantitative traits. We performed a case-control GWAS in the UK Biobank using recorded diagnosis of NAFLD based on diagnostic codes recommended in recent consensus guidelines. We performed a GWAS of 4,761 cases of NAFLD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34535985
DOI: 10.1002/hep4.1805
PMCID: PMC8793997

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