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BRAF mutations in KIT/PDGFRA positive gastrointestinal stromal tumours (GISTs): Is their frequency underestimated?

Pathology, research and practice - 1 Nov 2020

Jašek Karin, Váňová Barbora, Grendár Marián, Štanclová Andrea, Szépe Peter, Hornáková Andrea, Holubeková Veronika, Plank Lukáš, Lasabová Zora

Abstract excerpt

BRAF V600E mutations in GISTs are considered to be one of the mutational events in KIT/PDGFRA negative or positive GISTs, respectively. BRAF mutated GISTs usually do not respond to imatinib treatment, even more GISTs with imatinib sensitive KIT mutation. However, they are almost phenotypically and morphologically identical with KIT/PDGFRA positive GISTs. In general, due to the small number of BRAF mutations in...

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PMID: 32836055
DOI: 10.1016/j.prp.2020.153171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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