Article
Piezo1-Mediated Ca2+ Activities Regulate Brain Vascular Pathfinding during Development.
Neuron - 14 Oct 2020
Liu Ting-Ting, Du Xu-Fei, Zhang Bai-Bing, Zi Hua-Xing, Yan Yong, Yin Jiang-An, Hou Han, Gu Shan-Ye, Chen Qi, Du Jiu-Lin
Abstract excerpt
During development, endothelial tip cells (ETCs) located at the leading edge of growing vascular plexus guide angiogenic sprouts to target vessels, and thus, ETC pathfinding is fundamental for vascular pattern formation in organs, including the brain. However, mechanisms of ETC pathfinding remain largely unknown. Here, we report that Piezo1-mediated Ca2+ activities at primary branches of ETCs regulate branch...
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