Molecular Pathways: The Necrosome—A Target for Cancer Therapy

Abstract excerpt

Abstract Necroptosis is a caspase-8–independent cell death that requires coactivation of receptor-interacting protein 1 (RIP1) and receptor-interacting protein 3 (RIP3) kinases. The necrosome is a complex consisting of RIP1, RIP3, and Fas-associated protein with death domain leading to activation of the pseudokinase mixed lineage kinase like followed by a rapid plasma membrane rupture and inflammatory response...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autophagy in Disease and Therapy
• Share to Cell death mechanisms and regulation
• Share to Phagocytosis and Immune Regulation