Mutagenic Consequences of Sublethal Cell Death Signaling.

Abstract excerpt

Many human cancers exhibit defects in key DNA damage response elements that can render tumors insensitive to the cell death-promoting properties of DNA-damaging therapies. Using agents that directly induce apoptosis by targeting apoptotic components, rather than relying on DNA damage to indirectly stimulate apoptosis of cancer cells, may overcome classical blocks exploited by cancer cells to evade apoptotic cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Death
• Share to Cell death mechanisms and regulation
• Share to DNA Damage