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PAX6, modified by SUMOylation, plays a protective role in corneal endothelial injury

12 Aug 2020

Abstract excerpt

Abstract Treating corneal endothelial diseases tends to be challenging as human corneal endothelial cells (CECs) do not proliferate in vivo. The pathogenesis or mechanisms underlying injured CECs need further studies. The abnormal expression of PAX6, which is an essential transcription factor for corneal homeostasis, exhibits corneal endothelial defects. However, the effects of PAX6 protein involved in corneal...

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PMID: 32826860
DOI: 10.1038/s41419-020-02848-5

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