Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

18 Apr 2025

Abstract excerpt

Purpose: This study aimed to elucidate how Pax6 directly regulates Raver2 and sFlt-1 expression in corneal epithelial cells to maintain the cornea's avascular privilege during normal development. Methods: The expression levels of Pax6, Raver2, and sFlt-1 in both the mouse cornea and human corneal epithelial cell line (HCE-T) were evaluated. Changes in Raver2 and sFlt-1 expression following Pax6 knockdown were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal surgery and disorders
Share to Corneal Surgery and Treatments
Share to Developmental Biology and Gene Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40249603
DOI: 10.1167/iovs.66.4.52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular PrivilegePMID 40249603Read ↗

Cell signaling pathways in human mutant PAX6 corneal cells: an in vitro model for aniridia-related keratopathySemantic proximity Read ↗

PAX6–WNK2 Axis Governs Corneal Epithelial HomeostasisSemantic proximity Read ↗

Effects of miR-204-5p modulation on PAX6 regulation and corneal inflammationSemantic proximity Read ↗

Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation.Semantic proximity Read ↗

PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific GenesSemantic proximity Read ↗

Loss of Corneal Raver2 Expression in Aniridia Associated KeratopathySemantic proximity Read ↗

Core transcription regulatory circuitry orchestrates corneal epithelial homeostasisSemantic proximity Read ↗

Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature developmentSemantic proximity Read ↗

The single-cell transcriptomic atlas and RORA-mediated 3D epigenomic remodeling in driving corneal epithelial differentiationSemantic proximity Read ↗

A mouse model of aniridia reveals the in vivo downstream targets of Pax6 driving iris and ciliary body development in the eye.Semantic proximity Read ↗

PAX6 regulates human corneal epithelium cell identitySemantic proximity Read ↗

PAX6, modified by SUMOylation, plays a protective role in corneal endothelial injurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.