Article
Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice.
Molecular brain - 21 Aug 2020
Almeida Silva Luiz F, Reschke Cristina R, Nguyen Ngoc T, Langa Elena, Sanz-Rodriguez Amaya, Gerbatin Rogerio R, Temp Fernanda R, de Freitas Mayara L, Conroy Ronan M, Brennan Gary P, Engel Tobias, Henshall David C
Abstract excerpt
MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. Sequencing as well as functional studies using antisense oligonucleotides indicate important roles for microRNAs during the development of epilepsy through targeting transcripts involved in neuronal structure, gliosis and inflammation. MicroRNA-22 (miR-22) has been reported to protect against the development of...
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