Back to search

Article

Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy

2023-06-03

Abstract excerpt

The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, ideally measurable in a biofluid such as blood. Experimental and human epilepsy are associated with altered brain and blood levels of various microRNAs (miRNAs). Evidence is lacking, however, as to whether any of the circulating pool of miRNAs originates from the brain. To explore the link between...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4b4a7e0a-c058-5233-9978-cf44bc47f968
DOI
10.1101/2023.06.02.542426
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsyDOI 10.1101/2023.06.02.542426
Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsySemantic proximity
Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy.Semantic proximity
Circulating microRNAs and isomiRs as biomarkers for the initial insult and epileptogenesis in four experimental epilepsy models: The EPITARGET studySemantic proximity
Expression and Potential Function of Plasma Exosomal microRNAs (miR-483-5p, miR-671-5p, and miR-150-3p) in a Mouse Mode and in Mesial Temporal Lobe Epilepsy PatientsSemantic proximity
MicroRNAs in epilepsy: pathophysiology and clinical utilitySemantic proximity
Serum MicroRNAs as Predictors of Diagnosis and Drug-resistance in Temporal Lobe Epilepsy: A Preliminary StudySemantic proximity
Circulating miRNAs expression profiling in drug-resistant epilepsy: Up-regulation of miR-301a-3p in a case of sudden unexpected deathSemantic proximity
Expression of microRNA-129-2-3p and microRNA-935 in plasma and brain tissue of human refractory epilepsySemantic proximity
Impaired microglial phagocytosis promotes seizure developmentSemantic proximity
Exosomes in Epilepsy of Tuberous Sclerosis Complex: Carriers of Pro-Inflammatory MicroRNAsSemantic proximity
Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice.Semantic proximity
Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy.Semantic proximity
Select a neighboring publication to make it the new centre.