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Article

CpG Site-Specific Regulation of Metallothionein-1 Gene Expression.

International journal of molecular sciences - 19 Aug 2020

Ogushi Shoko, Yoshida Yuya, Nakanishi Tsuyoshi, Kimura Tomoki

Abstract excerpt

Metal-binding inducible proteins called metallothioneins (MTs) protect cells from heavy-metal toxicity. Their transcription is regulated by metal response element (MRE)-binding transcription factor-1 (MTF1), which is strongly recruited to MREs in the MT promoters, in response to Zn and Cd. Mouse Mt1 gene promoter contains 5 MREs (a-e), and MTF1 has the highest affinity to MREd. Epigenetic changes like DNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32824906
DOI: 10.3390/ijms21175946
PMCID: PMC7503544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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