Article
The C-terminal sequence of the large hepatitis delta antigen is variable but retains the ability to bind clathrin.
Virology journal - 16 Mar 2009
Wang Yu-Cheng, Huang Chi-Ruei, Chao Mei, Lo Szecheng J
Abstract excerpt
BACKGROUND: Hepatitis delta virus (HDV) is a defected RNA virus and requires its encoded large antigen (LDAg) to interact with helper viral proteins (HBsAgs) during assembly. Recently, a study demonstrated a direct binding of the LDAg C-terminus from genotype I HDV to the clathrin heavy chain (CHC), which suggests that this interaction might facilitate HDV assembly. If LDAg binding to clathrin is essential to HDV...
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