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Article

Dual topology of the processed hepatitis C virus protein NS4B is influenced by the NS5A protein

9 Oct 2006

Abstract excerpt

Among the least-known hepatitis C virus proteins is the non-structural protein 4B (NS4B). It localizes to the endoplasmic reticulum (ER) membrane and induces membrane changes, resulting in a membranous web that is reported to be the locale for virus replication. A model was presented previously for the topology of recombinant HCV NS4B of the 1a genotype based on in vitro data. In this model, the N-terminal tail...

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PMID: 17030859
DOI: 10.1099/vir.0.82211-0

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