Article
HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2020
Rosenbaum Evan, Seier Kenneth, Bandlamudi Chaitanya, Dickson Mark, Gounder Mrinal, Keohan Mary L, Chi Ping, Kelly Ciara, Movva Sujana, Nacev Benjamin, Simeone Noemi, Donoghue Mark, Slotkin Emily K, Qin Li-Xuan, Antonescu Cristina R, Tap William D, D'Angelo Sandra P
Abstract excerpt
PURPOSE: To determine if a targeted exome panel utilizing matched normal DNA can accurately detect germline and somatic HLA genes in patients with synovial sarcoma (SS) and whether select HLA-A*02 genotypes are prognostic or predictive of outcome in metastatic SS. EXPERIMENTAL DESIGN: Patients with metastatic SS consented to HLA typing by a Clinical Laboratory Improvement Amendments (CLIA)-certified test to...
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