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Article

SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2014

Dogan Irem, Kawabata Shigeru, Bergbower Emily, Gills Joell J, Ekmekci Abdullah, Wilson Willie, Rudin Charles M, Dennis Phillip A

Abstract excerpt

OBJECTIVES: Primary and acquired resistance to EGFR TKIs in EGFR mutant lung cancer occurs primarily through secondary mutations in EGFR or Met amplification. Drug resistance can also be mediated by expression of pluripotency transcription factors, such as OCT4, SOX2 and NANOG that decrease termi...

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Source

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Identifiers

PMID: 24746758
DOI: 10.1016/j.lungcan.2014.03.021
PMCID: PMC4058091

Genes

SOX2
EGFR
NANOG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24746758-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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