Article
The rs7911488-T allele promotes the growth and metastasis of colorectal cancer through modulating miR-1307/PRRX1.
Cell death & disease - 7 Aug 2020
Yang Man, Liu Xinchang, Meng Fanyi, Zhang Yawen, Wang Mengmeng, Chen Yinshuang, Guo Xuqin, Chen Weichang, Wang Weipeng
Abstract excerpt
We previously discovered that rs7911488T>C in pre-miR-1307 was closely correlated to the risk of colorectal cancer (CRC). However, the roles of rs7911488 in CRC are still largely unknown. Here we explored the roles of rs7911488 in the growth and metastasis of CRC. We firstly generated cell lines SW480-T and SW480-C for stable expression of rs7911488 T-allelic and C-allelic pre-miR-1307, respectively. We...
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