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Article

Polymorphism rs2682818 participates in the progression of colorectal carcinoma via miR-618-TIMP1 regulatory axis.

Scientific reports - 30 Nov 2021

Shao Wei, Xia Haina, Lan Qiangfang, Gu Jialu, Huang Haidong, Zheng Fei, Zheng Youyou

Abstract excerpt

Colorectal carcinoma (CRC) has a high morbidity and mortality. Current studies have confirmed a variety of microRNA polymorphisms were associated with tumor susceptibility, however, the mechanisms are still unknown. In this study, we were aimed to clarify how polymorphism rs2682818 participated in the progression of CRC. First of all, the differential expression of miR-618 was assessed by quantitative real-time...

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Cell Survival
HCT116 Cells
Kaplan-Meier Estimate
Mice, Inbred BALB C

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Neoplasm Transplantation

Tissue Inhibitor of Metalloproteinase-1

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PMID: 34848810
DOI: 10.1038/s41598-021-02613-4
PMCID: PMC8632919

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