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Article

Plasma apolipoprotein E levels and risk of dementia: A Mendelian randomization study of 106,562 individuals.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2018

Rasmussen Katrine L, Tybjærg-Hansen Anne, Nordestgaard Børge G, Frikke-Schmidt Ruth

Abstract excerpt

INTRODUCTION: In recent prospective studies, low plasma levels of apolipoprotein E (apoE) are associated with high risk of dementia. Whether this reflects a causal association remains to be established. METHODS: Using a Mendelian randomization approach, we studied 106,562 and 75,260 individuals from the general population in observational and genetic analyses, respectively. RESULTS: In observational analyses risk...

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PMID: 28774656
DOI: 10.1016/j.jalz.2017.05.006

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APOE

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