Article
An Immunosuppressive Effect of Melanoma-derived Exosomes on NY-ESO-1 Antigen-specific Human CD8+ T Cells is Dependent on IL-10 and Independent of BRAFV600E Mutation in Melanoma Cell Lines.
Immunological investigations - 1 Oct 2020
Shu ShinLa, Matsuzaki Junko, Want Muzamil Y, Conway Alexis, Benjamin-Davalos Shawna, Allen Cheryl L, Koroleva Marina, Battaglia Sebastiano, Odunsi Adekunle, Minderman Hans, Ernstoff Marc S
Abstract excerpt
Exosomes, including human melanoma-derived exosomes (HMEX), are known to suppress the function of immune effector cells, which for HMEX has been associated with the surface presence of the immune checkpoint ligand PD-L1. This study investigated the relationship between the BRAF mutational status of melanoma cells and the inhibition of secreted HMEX exosomes on antigen-specific human T cells. Exosomes were...
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