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Effect of Nasopharyngeal Carcinoma-Derived Exosomes on Human Regulatory T Cells

12 Dec 2014

Abstract excerpt

BACKGROUND: Regulatory T cells (Treg) and tumor-exosomes are thought to play a role in preventing the rejection of malignant cells in patients bearing nasopharyngeal carcinoma (NPC). METHODS: Treg recruitment by exosomes derived from NPC cell lines (C15/C17-Exo), exosomes isolated from NPC patients' plasma (Patient-Exo), and CCL20 were tested in vitro using Boyden chamber assays and in vivo using a xenograft SCID...

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PMID: 25505237
DOI: 10.1093/jnci/dju363

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