Article
Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.
The Journal of clinical investigation - 1 Aug 2003
Li Yingjian, Yang Junwei, Dai Chunsun, Wu Chuanyue, Liu Youhua
Abstract excerpt
Under pathologic conditions, renal tubular epithelial cells can undergo epithelial to mesenchymal transition (EMT), a phenotypic conversion that is believed to play a critical role in renal interstitial fibrogenesis. However, the underlying mechanism that governs this process remains largely unknown. Here we demonstrate that integrin-linked kinase (ILK) plays an important role in mediating tubular EMT induced by...
Topics
- Androstadienes
- Animals
- Biocompatible Materials
- Blotting, Northern
- Blotting, Western
- Cell Line
- Cell Movement
- Collagen
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Drug Combinations