Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.

The Journal of clinical investigation - 1 Aug 2003

Li Yingjian, Yang Junwei, Dai Chunsun, Wu Chuanyue, Liu Youhua

Abstract excerpt

Under pathologic conditions, renal tubular epithelial cells can undergo epithelial to mesenchymal transition (EMT), a phenotypic conversion that is believed to play a critical role in renal interstitial fibrogenesis. However, the underlying mechanism that governs this process remains largely unknown. Here we demonstrate that integrin-linked kinase (ILK) plays an important role in mediating tubular EMT induced by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Androstadienes
Share to Biocompatible Materials

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique, Indirect

Share to Matrix Metalloproteinase 2

Share to Matrix Metalloproteinase 9

Share to p38 Mitogen-Activated Protein Kinases

Share to Smad2 Protein

Share to Wortmannin

Source

Open in PubMed Open full text

Identifiers

PMID: 12925691
DOI: 10.1172/JCI17913
PMCID: PMC171389

Genes

ILK
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.PMID 12925691Read ↗

The differential expression of TGF-β1, ILK and wnt signaling inducing epithelial to mesenchymal transition in human renal fibrogenesis: an immunohistochemical study.Semantic proximity Read ↗

Targeting Integrin-Linked Kinase Suppresses Invasion and Metastasis through Downregulation of Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma.Semantic proximity Read ↗

Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis.Semantic proximity Read ↗

Expression of ILK in renal stroma is essential for multiple aspects of renal development.Semantic proximity Read ↗

Integrin-linked kinase – essential roles in physiology and cancer biologySemantic proximity Read ↗

Intratubular epithelial-mesenchymal transition and tubular atrophy after kidney injury in mice.Semantic proximity Read ↗

Integrin-linked kinase mediates CTGF-induced epithelial to mesenchymal transition in alveolar type II epithelial cells.Semantic proximity Read ↗

Overexpression of integrin-linked kinase correlates with malignant phenotype in non-small cell lung cancer and promotes lung cancer cell invasion and migration via regulating epithelial-mesenchymal transition (EMT)-related genes.Semantic proximity Read ↗

Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity.Semantic proximity Read ↗

Integrins in Kidney DiseaseSemantic proximity Read ↗

Role of the TGF‑β/Smad signaling pathway in the transition from acute kidney injury to chronic kidney disease (Review)Semantic proximity Read ↗

TGF-β1/p53 signaling in renal fibrogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.