Article
A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells.
Brain, behavior, and immunity - 1 Nov 2020
Ormel Paul R, Böttcher Chotima, Gigase Frederieke A J, Missall Roy D, van Zuiden Welmoed, Fernández Zapata M Camila, Ilhan Dilara, de Goeij Michelle, Udine Evan, Sommer Iris E C, Priller Josef, Raj Towfique, Kahn René S, Hol Elly M, de Witte Lot D
Abstract excerpt
Different lines of evidence support a causal role for microglia in the pathogenesis of schizophrenia. However, how schizophrenia patient-derived microglia are affected at the phenotypic and functional level is still largely unknown. We used a recently described model to induce patient-derived microglia-like cells and used this to analyze changes in the molecular phenotype and function of myeloid cells in...
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