Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients.

Brain, behavior, and immunity - 1 Jan 2018

van Rees Geertje Frederique, Lago Santiago Guillermo, Cox David Alan, Tomasik Jakub, Rustogi Nitin, Weigelt Karin, Ozcan Sureyya, Cooper Jason, Drexhage Hemmo, Leweke F Markus, Bahn Sabine

Abstract excerpt

Abnormal activation of brain microglial cells is widely implicated in the pathogenesis of schizophrenia. Previously the pathophysiology of microglial activation was considered to be intrinsic to the central nervous system. We hypothesised that due to their perivascular localization, microglia can also be activated by factors present in circulating blood. Through application of high-content functional screening,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammation
Share to Microglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Schizophrenia

Source

Identifiers

PMID: 28988033
DOI: 10.1016/j.bbi.2017.10.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients.PMID 28988033Read ↗

The involvement of microglial activation in schizophreniaSemantic proximity Read ↗

Genetic contribution to microglial activation in schizophreniaSemantic proximity Read ↗

A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells.Semantic proximity Read ↗

Functional Genomic Profiling of Schizophrenia-Associated Genes Reveals Key Microglial RegulatorsSemantic proximity Read ↗

Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia.Semantic proximity Read ↗

Complete blood count-derived inflammatory markers and symptom phenotypes in schizophrenia spectrum disorders: A hierarchical clustering analysis.Semantic proximity Read ↗

Decreased TREM2 expression in prefrontal cortex induces cognitive impairment and sensorimotor gating deficits in schizophreniaSemantic proximity Read ↗

Immune-Related Genomic Schizophrenic Subtyping Identified in DLPFC TranscriptomeSemantic proximity Read ↗

Cerebrospinal fluid concentration of complement component 4A is increased in first-episode schizophreniaSemantic proximity Read ↗

CSF1R Contributes to Vascular Association of Microglia and Stress Regulation in SchizophreniaSemantic proximity Read ↗

The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorderSemantic proximity Read ↗

Peripheral biomarkers of treatment-resistant schizophrenia: Genetic, inflammation and stress perspectivesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.