Article
Determination of genetic changes of Rev-erb beta and Rev-erb alpha genes in Type 2 diabetes mellitus by next-generation sequencing.
Gene - 30 Dec 2020
Tokat Bengu, Kanca-Demirci Deniz, Gul Nurdan, Satman Ilhan, Ozturk Oguz, Ozder Aclan, Kucukhuseyin Ozlem, Yilmaz-Aydogan Hulya
Abstract excerpt
BACKGROUND: The nuclear receptors Rev-erb alpha and Rev-erb beta are transcription factors that regulate the function of genes in glucose and lipid metabolism, and they also form a link between circadian rhythm and metabolism. We evaluated the variations in Rev-erb alpha and Rev-erb beta genes together with biochemical parameters as risk factors in type 2 diabetic (T2DM) patients. METHODS: Molecular analyses of...
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