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Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose.

Pharmacogenetics and genomics - 1 Nov 2008

Dahlman Ingrid, Vaxillaire Martine, Nilsson Maria, Lecoeur Cecile, Gu Harvest F, Cavalcanti-Proença Christine, Efendic Suad, Ostenson Claes G, Brismar Kerstin, Charpentier Guillaume, Gustafsson Jan-Ake, Froguel Philippe, Dahlman-Wright Karin, Steffensen Knut R

Abstract excerpt

OBJECTIVE: Estrogen receptor 1 (ESR1) mediates effects of estrogens on glucose homeostasis. Polymorphisms in intron 1, 2, and 4 of the ESR1 gene have been found to be associated with type 2 diabetes (T2D) in Hungarian, Chinese, and African-American and European-American cohorts. The aim of this study was to investigate the association between ESR1 polymorphisms and T2D as well as quantitative phenotypes related...

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Source

Identifiers

PMID: 18854778
DOI: 10.1097/FPC.0b013e32831101ef

Genes

ESR1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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