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Article

Footprint of the host restriction factors APOBEC3 on the genome of human viruses

14 Aug 2020

Abstract excerpt

APOBEC3 enzymes are innate immune effectors that introduce mutations into viral genomes. These enzymes are cytidine deaminases which transform cytosine into uracil. They preferentially mutate cytidine preceded by thymidine making the 5'TC motif their favored target. Viruses have evolved different strategies to evade APOBEC3 restriction. Certain viruses actively encode viral proteins antagonizing the APOBEC3s,...

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PMID: 32797103
DOI: 10.1371/journal.ppat.1008718

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