Article
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2011
Wu Jian, Jiao Yuchen, Dal Molin Marco, Maitra Anirban, de Wilde Roeland F, Wood Laura D, Eshleman James R, Goggins Michael G, Wolfgang Christopher L, Canto Marcia I, Schulick Richard D, Edil Barish H, Choti Michael A, Adsay Volkan, Klimstra David S, Offerhaus G Johan A, Klein Alison P, Kopelovich Levy, Carter Hannah, Karchin Rachel, Allen Peter J, Schmidt C Max, Naito Yoshiki, Diaz Luis A, Kinzler Kenneth W, Papadopoulos Nickolas, Hruban Ralph H, Vogelstein Bert
Abstract excerpt
More than 2% of adults harbor a pancreatic cyst, a subset of which progresses to invasive lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of the pancreas, we determined the exomic sequences of DNA from the neoplastic epithelium of eight surgically resected cysts of each of the major neoplastic cyst types: serous cystadenomas (SCAs), intraductal papillary mucinous neoplasms...
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