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Article

EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution

14 Aug 2020

Abstract excerpt

Objective In multiplex MS families, we determined the humoral immune response to Epstein-Barr virus nuclear antigen 1 (EBNA-1)-specific immunoglobulin γ (IgG) titers in patients with MS, their healthy siblings, and biologically unrelated healthy spouses and investigated the role of specific genetic loci on the antiviral IgG titers. Methods IgG levels against EBNA-1 and varicella zoster virus (VZV) as control were...

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PMID: 32796079
DOI: 10.1212/nxi.0000000000000872

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