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Article

Modeling ALS using iPSCs: is it possible to reproduce the phenotypic variations observed in patients in vitro?

Regenerative medicine - 1 Jul 2020

Vasques Juliana Ferreira, Mendez-Otero Rosalia, Gubert Fernanda

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal disease that leads to progressive degeneration of motoneurons. Mutations in the C9ORF72, SOD1, TARDBP and FUS genes, among others, have been associated with ALS. Although motoneuron degeneration is the common outcome of ALS, different pathological mechanisms seem to be involved in this process, depending on the genotypic background of the patient. The advent of...

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Identifiers

PMID: 32795164
DOI: 10.2217/rme-2020-0067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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