Article
A streamlined CRISPR workflow to introduce mutations and generate isogenic iPSCs for modeling amyotrophic lateral sclerosis.
Methods (San Diego, Calif.) - 1 Jul 2022
Deneault Eric, Chaineau Mathilde, Nicouleau Michael, Castellanos Montiel Maria José, Franco Flores Anna Kristyna, Haghi Ghazal, Chen Carol X-Q, Abdian Narges, Shlaifer Irina, Beitel Lenore K, Durcan Thomas M
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) represents a complex neurodegenerative disorder with significant genetic heterogeneity. To date, both the genetic etiology and the underlying molecular mechanisms driving this disease remain poorly understood, although in recent years several studies have highlighted a number of genetic mutations causative for ALS. With these mutations pointing to potential pathways that may be...
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