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Article

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.

Nature medicine - 1 Oct 2018

Fujimori Koki, Ishikawa Mitsuru, Otomo Asako, Atsuta Naoki, Nakamura Ryoichi, Akiyama Tetsuya, Hadano Shinji, Aoki Masashi, Saya Hideyuki, Sobue Gen, Okano Hideyuki

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a heterogeneous motor neuron disease for which no effective treatment is available, despite decades of research into SOD1-mutant familial ALS (FALS). The majority of ALS patients have no familial history, making the modeling of sporadic ALS (SALS) essential to the development of ALS therapeutics. However, as mutations underlying ALS pathogenesis have not yet been identified,...

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Source

Identifiers

PMID: 30127392
DOI: 10.1038/s41591-018-0140-5

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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